Comprehensive Investigations Revealed Consistent Pathophysiological Alterations after Vaccination with COVID-19 Vaccines

13/11/2021

What exactly happens to your immune system after you take a traditional inactivated whole-virus Covid-19 vaccine? How exactly does its make you less likely to end up in hospital after catching the virus?

This research article suggests that one's immune system gets altered for the worse after receiving an inactivated SARS-CoV-2 Vaccine (Vero Cell) (China Biotechnology Group Corporation) by reducing the cell count of CD8+ T cells - powerful 'police' cells that help to identify viruses to be destroyed.

"..these data suggested that after vaccination, at least by day 28, other than generation of neutralizing antibodies, people's immune systems, including those of lymphocytes and monocytes, were perhaps in a more vulnerable state."

Liu, J., Wang, J., Xu, J. et al. Cell Discov 7, 99 (2021). https://doi.org/10.1038/s41421-021-00329-3, published 26 October 2021

Abstract

Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in COVID-19 patients, suggesting that vaccination mimicked an infection. Single-cell mRNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) before and 28 days after the first inoculation also revealed consistent alterations in gene expression of many different immune cell types. Reduction of CD8+ T cells and increase in classic monocyte contents were exemplary. Moreover, scRNA-seq revealed increased NF-κB signaling and reduced type I interferon responses, which were confirmed by biological assays and also had been reported to occur after SARS-CoV-2 infection with aggravating symptoms. 

Altogether, our study recommends additional caution when vaccinating people with pre-existing clinical conditions, including diabetes, electrolyte imbalances, renal dysfunction, and coagulation disorders.